全文获取类型
收费全文 | 174篇 |
免费 | 14篇 |
专业分类
化学 | 142篇 |
晶体学 | 4篇 |
力学 | 1篇 |
数学 | 13篇 |
物理学 | 28篇 |
出版年
2023年 | 1篇 |
2022年 | 2篇 |
2021年 | 2篇 |
2020年 | 10篇 |
2019年 | 6篇 |
2018年 | 3篇 |
2017年 | 2篇 |
2016年 | 17篇 |
2015年 | 3篇 |
2014年 | 10篇 |
2013年 | 18篇 |
2012年 | 9篇 |
2011年 | 7篇 |
2010年 | 11篇 |
2009年 | 9篇 |
2008年 | 6篇 |
2007年 | 12篇 |
2006年 | 15篇 |
2005年 | 12篇 |
2004年 | 13篇 |
2003年 | 4篇 |
2002年 | 7篇 |
2001年 | 3篇 |
2000年 | 2篇 |
1999年 | 1篇 |
1998年 | 1篇 |
1991年 | 1篇 |
1987年 | 1篇 |
排序方式: 共有188条查询结果,搜索用时 32 毫秒
21.
Derya Tarinc Burcu Dogan-Topal Aysegul Golcu Sibel A. Ozkan 《Journal of Analytical Chemistry》2014,69(9):899-908
A voltammetric study of the oxidation of Ceftazidime (CEFT) has been carried out at the glassy carbon electrode by cyclic, differential pulse (DPV) and square wave (SWV) voltammetry. The oxidation of CEFT was irreversible and exhibited diffusion controlled process depending on pH. The oxidation mechanism was proposed and discussed. According to the linear relationship between the peak current and concentration, DPV and SWV voltammetric methods for CEFT assay in pharmaceutical dosage forms and human urine were developed. For analytical purposes, a well resolved diffusion controlled voltammetric peak was obtained in 0.1 M H2SO4 at 1.00 and 1.02 V for differential pulse and square wave voltammetric techniques, respectively. The linear response was obtained within the range of 4 × 10?6?8 × 10?5 M with a detection limit of 6 × 10?7 M for differential pulse and 4 × 10?6–2 × 10?4 M with a detection limit of 1 × 10?6 M for square wave voltammetric technique. The determination of CEFT in 0.1 M H2SO4 was possible over the 2 × 10?6–1 × 10?4 M range in urine sample for both techniques. The standard addition method was used for the recovery studies. 相似文献
22.
Behrouz Seyfinejad Ali Meshkini Paria Habibolahi Sibel A. Ozkan Abolghasem Jouyban 《Electrophoresis》2020,41(9):666-677
Application of hollow fiber-based electromembrane extraction was studied for extraction and quantification of phenytoin from exhaled breath condensate (EBC). Phenytoin is extracted from EBC through a supported liquid membrane consisting of 1-octanol impregnated in the walls of a hollow fiber, and into an alkaline aqueous acceptor solution inside the lumen of the fiber. Under the obtained conditions of electromembrane extraction, that is, the extraction time of 15 min, stirring speed of 750 rpm, donor phase pH at 11.0, acceptor pH at 13.0, and an applied voltage of 15 V across the supported liquid membrane, an enrichment factor of 102-fold correspond to extraction percent of 25.5% was achieved. Good linearity was obtained over the concentration range of 0.001–0.10 µg/mL (r2 = 0.9992). Limits of detection and quantitation were 0.001 and 0.003 µg/mL, respectively. The proposed method was successfully applied to determine phenytoin from EBC samples of patients receiving the drug. No interfering peaks were detected that indicating excellent selectivity of the method. The intra- and interday precisions (RSDs) were less than 14%. 相似文献
23.
Kenan Can Tok Mehmet Gumustas Giorgi Jibuti Halit Sinan Suzen Sibel A. Ozkan Bezhan Chankvetadze 《Molecules (Basel, Switzerland)》2020,25(24)
In a recent study, opposite enantiomer elution order was observed for ketoprofen enantiomers on two amylose-phenylcarbamate-based chiral columns with the same chemical composition of the chiral selector but in one case with coated while in the other with an immobilized chiral selector. In the present study, the influence of this uncommon effect on method validation parameters for the determination of minor enantiomeric impurity in dexketoprofen was studied. The validated methods with two alternative elution orders for enantiomers were applied for the evaluation of enantiomeric impurity in six marketed dexketoprofen formulations from various vendors. In most of these formulations except one the content of enantiomeric impurity exceeded 0.1% (w/w). 相似文献
24.
Suniya Shahzad Leyla Karadurmus Burcu Dogan‐Topal Tugba Taskin‐Tok Afzal Shah Sibel A. Ozkan 《Electroanalysis》2020,32(5):912-922
An electrochemical dsDNA nanobiosensor was fabricated using amino‐functionalized multi walled carbon nanotubes modified glassy carbon electrode (NH2fMWCNTs/GCE) for the sensitive detection of DNA bases and electrochemical monitoring of drug‐DNA interaction. The influence of functional groups on MWCNT was studied by MWCNT functionalized with NH2 (NH2fMWCNTs) and COOH (COOHfMWCNT) groups based on the signal of DNA bases. The modified electrodes were characterized by scanning electron microscopy. One layer of calf thymus double stranded deoxyribonucleic acid (ct‐dsDNA) was immobilized onto the NH2fMWCNTs/GCE (dsDNA/NH2fMWCNTs/GCE). The dsDNA/NH2fMWCNTs/GCE were used to investigate the interaction between the dsDNA and the anticancer drug gemcitabine by differential pulse voltammetry in acetate buffer of pH 4.70. For the confirmation of interaction, the lowering in intensity of the current signals of guanine and adenine was considered as an indicator. Electrochemical impedance spectroscopy studies were performed for the comparison of the modified surfaces. In order to define and visualize the interaction mechanism between gemcitabine and dsDNA/NH2fMWCNTs/GCE at the molecular level, in silico methods including docking and molecular dynamics simulations were employed. 相似文献
25.
We describe a novel electrochemical technique for the nonlithographic, fluidic pick-and-place assembly of optoelectronic devices by electrical and optical addressing. An electrochemical cell was developed that consists of indium tin oxide (ITO) and n -type silicon substrates as the two electrode materials and deionized water (R = 18 MOmega) as the electrolytic medium between the two electrodes. 0.8-20-microm-diameter negatively charged polystyrene beads, 50-100-microm-diameter SiO(2) pucks, and 50-microm LED's were successfully integrated upon a patterned silicon substrate by electrical addressing. In addition, 0.8-microm-diameter beads were integrated upon a homogeneous silicon substrate by optical addressing. This method can be applied to massively parallel assembly (>1000 x 1000 arrays) of multiple types of devices (of a wide size range) with very fast (a few seconds) and accurate positioning. 相似文献
26.
Oil-based polyurethanes were synthesized from triglyceride oil-based hydroxyl containing material and toluene diisocyanate or hexamethylene diisocyanate for wound dressing applications. The reactions were carried out with or without catalyst at 90 °C. The amount of free isocyanate during the reaction was determined by a FTIR-ATR method, and the results were compared with those from a back-titration method. The data obtained were used for determination of kinetic parameters. 相似文献
27.
Polymers of diphenylamine-2-carboxylic acid are synthesized for the first time via chemical oxidative polymerization. The effects of the concentration of reagents, their ratio, and the temperature and time of reaction on the yield and chemical structure of poly(diphenylamine-2-carboxylic acid) are studied by IR and UV spectroscopy. It is shown that the growth of polymer chains proceeds through the C-C addition in the para position of phenyl rings relative to nitrogen. During the thermal oxidation of poly(diphenylamine-2-carboxylic acid), COOH groups and dopant molecules are successively eliminated; with a further increase in temperature, the polymer behaves as polydiphenylamine. The main processes of thermooxidative degradation of poly(diphenylamine-2-carboxylic acid) begin at 570°C. This value is 120°C higher than the corresponding parameter in the case of polydiphenylamine. 相似文献
28.
29.
A. Sinan Ozkan 《Mathematical Methods in the Applied Sciences》2020,43(7):4353-4359
In this study, we consider a boundary value problem generated by a second-order dynamic equation on a time scale and boundary conditions depending on the spectral parameter. We give some properties of the solutions and obtain a formulation of the number of eigenvalues of the problem. 相似文献
30.
Ann Gogolashvili Elene Tatunashvili Lali Chankvetadze Tamas Sohajda Mehmet Gumustas Sibel A. Ozkan Antonio Salgado Bezhan Chankvetadze 《Electrophoresis》2019,40(15):1904-1912
The major goal of this study was to determine the affinity pattern of brombuterol (BB) enantiomers toward various cyclodextrins (CD) and to evaluate the potential of NMR spectroscopy for understanding fine mechanisms of interactions between CDs and BB enantiomers. Separation of BB enantiomers was performed in a fused‐silica capillary using a phosphate buffer, pH 2.5, at the room temperature in the normal polarity mode. It was shown once again that CE in combination with NMR spectroscopy represents a very sensitive tool for studies of affinity patterns and structure of CD complexes with chiral guests. Although opposite affinity patterns of BB enantiomers were observed toward native β‐ and γ‐CDs, no significant differences between the structures of the complexes of these two CDs with BB were detected by NMR spectroscopy. In contrary to this, the opposite affinity pattern of BB enantiomers toward β‐CD and its two sulfated derivatives, heptakis (2,3‐O‐diacetyl‐6‐sulfo)‐β‐CD (HDAS‐β‐CD) and heptakis (2‐O‐methyl‐3,6‐di‐O‐sulfo)‐β‐CD (HMDS‐β‐CD) was associated with major differences in the structure of the complexes. In addition, it was shown again that HMDS‐β‐CD provides separation of enantiomers without formation of inclusion‐type complex with the chiral analyte. 相似文献